Wednesday, November 9, 2016

Interesting View on Steroids

Image result for usa weightlifting
Are American lifters clean in 2016? I really believe they are.

Here is an article that was posted on the Supertraining Forum that was started by the late Mel Siff. The pendulum swings back and forth. My modest athletic career began quite a while before AAS were illegal. In the early days the claims from the medical field and athletic administrators about the dangers were exagerrated. Then there have been those who purport that there are no risks at all. Over the years a more balanced perspective developed. As with anything, time filters out the truth. Now many decades later we can get a better look at actual long term results. I am sure there are those who would dispute or disregard the research presented, but on the other hand, I'm glad I didn't get involved in the chemical side of athletic preparation. Getting older is tough enough without added complications. Train hard,train smart, live a balanced life. We really have no control over the length of our time here, but we have a lot to do with the quality of our life. Enjoy the journey and Happy Thanksgiving!

A common refrain amongst apologists for anabolic steroids is : Where are the
bodies? The bodies are in the cemetary ony the death certificated does not
state they died from steroids. The most likely cause of death heart disease.
It might be cardiac arrhythmia or acute MI.

There is an excellent article in the American Journal of Cardiology which
reviews A total of 49 studies describing 1,467 athletes were reviewed to
investigate the cardiovascular effects of the abuse of AAS.
It cites 99 articles covering this topic. If you are interested in this topic
go to your local hospital Library and check out :

Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids,
Blood Pressure, Left Ventricular Dimensions, and Rhythm
The American Journal of Cardiology - Volume 106, Issue 6 (September 2010) -
Copyright © 2010 The American College of Cardiology -

Because of copyright and space I cannot put the article here but I have taken
the time to excerpt some of the information I thought might be pertinent along
with the articles or journals cited.

You are not likely to find these studies in your typical muscle magazine or
website. Some of these studies date back to the mid 80s and 90s. The
information is not new just conveniently ignored.

************ ********* **

Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids,
Blood Pressure, Left Ventricular Dimensions, and Rhythm
The American Journal of Cardiology - Volume 106, Issue 6 (September 2010) -
Copyright © 2010 The American College of Cardiology -

AAS and abnormal plasma lipoproteins
AAS abuse has been linked with abnormal plasma lipoproteins (Table 1). Several
studies suggest that AAS abuse in athletes increase low-density lipoprotein
(LDL) levels by >20% [14] , [36] , [37] , [38] and decrease high-density lipoprotein
(HDL) levels by 20% to 70%. [13] , [14] , [37] , [39] , [40] , [41] , [42] ,
[43] , [44]

By some estimates, these lipoprotein abnormalities increase
the risk for coronary artery disease by three- to sixfold. [14] , [45]

13 Sader M.A., Griffiths K.A., McCredie R.J., Handelsman D.J., Celermajer
D.S.: Androgenic anabolic steroids and arterial structure and function in male
bodybuilders. J Am Coll Cardiol 37. 224-230.2001; Abstract

14 Lenders J.W., Demacker P.N., Vos J.A., Jansen P.L., Hoitsma A.J., Van't Laar
A., Thien T.: Deleterious effects of anabolic steroids on serum lipoproteins,
blood pressure, and liver function in amateur bodybuilders. Int J Sports Med 9.
19-23.1988; Abstrac
36 Lajarin F., Zaragoza R., Tovar I., Martinez-Hernandez P.: Evolution of
serum lipids in two male bodybuilders using anabolic steroids. Clin Chem 42.
970- 972.1996; Abstract
37 McKillop G., Ballantyne D.: Lipoprotein analysis in bodybuilders. Int J
Cardiol 17. 281-288.1987; Abstract

38 Palatini P., Giada F., Garavelli G., Sinisi F., Mario L., Michieletto M.,
Baldo-Enzi G.: Cardiovascular effects of anabolic steroids in weight-trained
subjects. J Clin Pharmacol 36. 1132-1140.1996; Abstract
39 Baldo-Enzi G., Giada F., Zuliani G., Baroni L., Vitale E., Enzi G.,
Magnanini P., Fellin R.: Lipid and apoprotein modifications in body builders
during and after self- administration of anabolic steroids. Metabolism 39. 203-208.1990; Abstract
40 Fröhlich J., Kullmer T., Urhausen A., Bergmann R., Kindermann W.: Lipid
profile of body builders with and without self-administration of anabolic
steroids. Eur J Appl Physiol 59. 98-103.1989; 41 Hartgens F., Rietjens G., K
41 Hartgens F., Rietjens G., Keizer H.A., Kuipers H., Wolffenbuttel B.:
Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a).
Br J Sport Med 38. 253-259.2004;

42 Lane H., Grace F., Smith J.C., Morris K., Cockcroft J., Scanlon M.F., Davies
J.S.: Impaired vasoreactivity in bodybuilders using androgenic anabolic
steroids. Eur J Clin Invest 36. 483-488.2006; Abstract

43 Urhausen A., Albers T., Kindermann W.: Are the cardiac effects of anabolic
steroid abuse in strength athletes reversible?. Heart 90. 496-501.2004;

44 Zuliani U., Bernardini B., Catapano A., Campana M., Cerioli G., Spattini
M.: Effects of anabolic steroids, testosterone, and HGH on blood lipids and
echocardiographic parameteres in body builders. Int J Sports Med 10.
62-66.1989; Abstract

45 Glazer G.: Atherogenic effects of anabolic steroids on serum lipid levels.
A literature reviewArch Intern Med 151. 1925-1933.1991; Abstract

AAS, acute MI, and sudden death
Alarming data have linked AAS with fatal events, although these are mostly
case-control studies and case reports of acute coronary syndromes, MIs, and
ventricular arrhythmias. [24] , [46] , [83] , [84] , [85] , [86] , [87] , [88]

88 Fineschi V., Riezzo I., Centini F., Silingardi E., Licata M., Beduschi G.,
Karch S.B.: Sudden cardiac death during anabolic steroid abuse: morphologic and
toxicologic findings in two fatal cases of bodybuilders. Int J Legal Med 121.
48-53.2007; Abstract

89 Sullivan M.L., Martinez C.M., Gennis P., Gallagher E.J.: The cardiac
toxicity of anabolic steroids. Prog Cardiovasc Dis 41. 1-15.1998; Abstract

90 Ferenchick G.: Anabolic/androgenic steroid abuse and thrombosis: is there a
connection?. Med Hypotheses 35. 27-31.1991; Abstract

91 Roeggia M., Heinz G., Werba E., Roeggla G.: Cardiac tamponade in a
21-year-old body builder with anabolica abuse. Br J Clin Pract 50.
411-412.1996; Citation

92 Ferenchick G., Adelman S.: Myocardial infarction associated with anabolic
steroid use in a previously healthy 37-year-old weight lifter. Am Heart J 124.
507- 508.1992; Citation

93 Huie M.: An acute myocardial infarction occurring in an anabolic steroid
user. Med Sci Sport Exer 26. 408-413.1994;

94 Fisher M., Appleby M., Rittoo D., Cotter L.: Myocardial infarction with
extensive intracoronary thrombus induced by anabolic steroids. Br J Clin Pract
50. 222- 223.1996; Abstract

a postmortem study of male Caucasian AAS abusers (aged 20 to 45 years) suggested
primary cardiac pathology in 1/3, [23]

23 Thiblin I., Lindquist O., Rajs J.: Cause and manner of death among users of
anabolic androgenic steroids. J Forensic Sci 45. 16-23.2000; Abstract

recent case-control study [24] , [25] suggested cardiac causes in 2/3 of deaths,
with others being attributed to suicide, hepatic coma, and malignancy.

24 Parssinen M., Kujala U., Vartiainen E., Sarna S., Seppala T.: Increased
premature mortality of competitive powerlifters suspected to have used anabolic
agents. Int J Sports Med 21. 225-227.2000; Abstract

25 Parssinen M., Seppala T.: Steroid use and long-term health risks in former
athletes. Sports Med 2002. 83-84.2002; 2
Hausmann et al [84] describe a 23-year-old male bodybuilder who abused AAS and
experienced sudden cardiac arrest. Postmortem examination revealed ventricular
hypertrophy, myocardial fibrosis, and acute MI, and the cause of death was
attributed to arrhythmic sudden death secondary to AAS abuse.

84 Hausmann R., Hammer S., Betz P.: Performance enhancing drugs (doping agents)
and sudden death—a case report and review of the literature. Int J Legal Med
111. 261-264.1998; Abstrac

McNutt et al[46] reported an acute MI in a 22-year-old bodybuilder who admitted
to AAS abuse but lacked cardiac risk factors. The patient presented with
markedly elevated LDL (596 mg/dl) and depressed HDL (14 mg/dl) yet had no family
history of premature atherosclerosis or cardiac events. Within a month of
discontinuing AAS, his LDL decreased to 220 mg/dl and his HDL increased to 35

46 McNutt R.A., Ferenchick G.S., Kirlin P.C., Hamlin N.J.: Acute myocardial
infarction in a 22-year-old world class weight lifter using anabolic steroids.
Am J Cardiol62.164. 1988; Citation

49 Bowman S.: Anabolic steroids and infarction. BMJ 300. 750.1990; Citation

Figure 1 shows the presenting electrocardiogram of a 25-year-old male athlete
who abused nandrolone and presented with an acute MI without traditional cardiac
risk factors. Acute angiography revealed extensive left anterior descending
coronary artery thrombosis, which was managed by thrombolysis. Angiography in
the subacute phase confirmed very mild luminal irregularity at the site of
previous thrombosis.

69 Kennedy C.: Myocardial infarction in association with misuse of anabolic
steroids. Ulster Med J 62. 174-176.1993; Citation

The most commonly observed arrhythmias, typically occurring during physical
exertion, include atrial fibrillation, ventricular fibrillation, ventricular
tachycardia, and supraventricular and ventricular ectopic beats. [95]
95 Furlanello F., Serdoz L.V., Cappato R., De Ambroggi L.: Illicit drugs and
cardiac arrhythmias in athletes. Eur J Cardiovasc Prev Rehabil 14. 487-494.2007;

Dickerman et al [96] reported a 20-year-old male bodybuilder who
self-administered AAS 700 mg/week and had sudden cardiac arrest. Autopsy
indicated LVH with a cardiac mass >2 times the upper limit of normal.

96 Dickerman R.D., Schaller F., Prather I., McConathy W.J.: Sudden cardiac death
in a 20-year-old bodybuilder using anabolic steroids. Cardiology 86.
172-173.1995; Abstract

************ ******
Ralph Giarnella MD
Southington Ct. USA

I can't say the same for "bodybuilding" clowns though.

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